SARS-CoV-2 variants do not evolve to promote further escape from MHC-I recognition.

Miyu Moriyama Carolina LucasValter Silva Monteironull nullAkiko Iwasak

Published in: bioRxiv : the preprint server for biology (2022)

Moriyama et al. demonstrate that SARS-CoV-2 variants of concern retain similar MHC-I downregulation capacity compared to the ancestral virus. The results suggest that MHC-I evasion capacity is optimized in the ancestral virus and thus further adaptation was not observed.

Keyphrases

sars cov
copy number
respiratory syndrome coronavirus
signaling pathway
disease virus
genome wide
dna methylation