MnO 2 Decorated Metal-Organic Framework-Based Hydrogel Relieving Tumor Hypoxia for Enhanced Photodynamic Therapy.

Photodynamic therapy (PDT) has emerged as a promising cancer treatment modality; however, its therapeutic efficacy is greatly limited by tumor hypoxia. In this study, wedesigned a metal-organic framework-based hydrogel (MOF Gel) system that synergistically combines PDT with supply of oxygen. Porphyrin-based Zr-metal-organic framework nanoparticles weresynthesized as the photosensitizer. MnO 2 wasdecorated onto the surface of the MOF, which can effectively convert H₂O₂ into oxygen. Simultaneously, the incorporation of MnO 2 -decorated MOF (MnP NPs) into a chitosan hydrogel (MnP Gel) serves to enhance its stability and retention within the tumor microenvironment. The results showed that this integrated approach significantly improved tumor inhibition efficiency by relieving tumor hypoxia and enhancing PDT. Overall, ourfindings underscore the potential for employing nano-MOF-based hydrogel systems as promising agents for cancer therapy, thus advancing the application of multifunctional MOFs in cancer treatment. This article is protected by copyright. All rights reserved.