New perspectives for prosthetic valve endocarditis - impact of molecular imaging by FISHseq diagnostics.
Maria M HajduczeniaFrank R KlefischAlexander G M HopfHerko GrubitzschMiriam S StegemannFrieder PfäfflinBirgit PuhlmannMichele OckenLucie KretzlerDinah von SchöningVolkmar FalkAnnette MoterJudith KikhneyPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
FISHseq improves PVE diagnostics, complementing the conventional cultural methods. In addition to species identification, FISH provides information about the severity of PVE and state of the pathogens, e.g. stage of biofilm formation, activity and localization on and within the prosthetic material. As a molecular imaging technique, FISHseq enables the unambiguous discrimination of skin flora as contaminant or infectious agent.