Inference about causation between body mass index and DNA methylation in blood from a twin family study.

Shuai LiEe Ming WongMinh BuiTuong L NguyenJi-Hoon Eric JooJennifer StoneGillian S DitePierre-Antoine DuguéJonathan BeesleyGraham G GilesRichard SafferyMelissa C SoutheyJohn L Hopper

Published in: International journal of obesity (2005) (2018)

For middle-aged women, peripheral blood DNA methylation at several genomic locations is associated with current BMI, BMI at age 18-21 years and BMI change. Our study suggests that BMI has a causal effect on peripheral blood DNA methylation.

Keyphrases

dna methylation
peripheral blood
body mass index
genome wide
gene expression
weight gain
middle aged
copy number
single cell
pregnant women
adipose tissue
polycystic ovary syndrome
skeletal muscle
pregnancy outcomes