Genipin crosslinked quaternary ammonium chitosan hydrogels potential for wound dressings.
Ling WangXiaoyue DingJingyu LiMan LiPeng DingWei GuoQiaoyun WuYanfang SunGuohua JiangOseweuba Valentine OkoroMahta MirzaeiAmin ShavandiLihong FanLei NiePublished in: Biomedical materials (Bristol, England) (2024)
Bacterial infection can lead to various complications, such as inflammations on surrounding tissues, which can prolong wound healing and thus represent a significant clinical and public healthcare problem. Herein, a report on the fabrication of a novel genipin/quaternized chitosan hydrogel for wound dressing fabrication is presented. The hydrogel was prepared by simply mixing quaternized chitosan and genipin under 35 oC bath without further purification. The obtained hydrogels exhibited porous structure (250 ~ 500 μm) and excellent mechanical properties (3000 ~ 6000 Pa). In addition, the hydrogels displayed good self-healing ability and adhesion performance on different substrates. Genipin crosslinked quaternized chitosan hydrogels also performed good antibacterial activities against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The CCK-8 and fluorescent images confirmed the cytocompatibility of hydrogels by seeding with NIH-3T3 cells. Based on the above results, the present study was able to show that the prepared hydrogel has the potential to be used as wound dressing in biomedical fields.
Keyphrases
- wound healing
- hyaluronic acid
- escherichia coli
- healthcare
- staphylococcus aureus
- tissue engineering
- drug delivery
- biofilm formation
- gene expression
- mental health
- emergency department
- deep learning
- risk factors
- optical coherence tomography
- cystic fibrosis
- extracellular matrix
- convolutional neural network
- multidrug resistant
- low cost
- metal organic framework
- adverse drug