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Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes.

Venexia M WalkerMarijana VujkovicAlice Rose CarterNeil Martin DaviesMiriam S UdlerMichael G LevinGeorge Davey SmithBenjamin F VoightTom R GauntScott M Damrauer
Published in: Diabetologia (2022)
Most traits were found to affect liability to atherosclerotic CVD independently of their relationship with liability to type 2 diabetes. These traits are therefore important for understanding atherosclerotic CVD risk regardless of an individual's liability to type 2 diabetes.
Keyphrases
  • type diabetes
  • cardiovascular disease
  • glycemic control
  • genome wide
  • insulin resistance
  • gene expression
  • coronary artery disease
  • cardiovascular events
  • skeletal muscle