Imipenem/funobactam (formerly XNW4107) in vivo pharmacodynamics against serine carbapenemase-producing Gram-negative bacteria: a novel modelling approach for time-dependent killing.

Andrew J FratoniAngela V BerryXiao LiuXi ChenYuchuan WuYasmeen AbouelhassanKamilia Abdelraouf

Published in: The Journal of antimicrobial chemotherapy (2023)

Imipenem/funobactam showed potent in vivo efficacy against serine carbapenemase-producers. The novel PK/PD index (%fT > CT)/MIC appeared to best describe in vivo activity.

Keyphrases

klebsiella pneumoniae
acinetobacter baumannii
gram negative
protein kinase
multidrug resistant
computed tomography
drug resistant
escherichia coli
image quality
contrast enhanced
dual energy
pseudomonas aeruginosa
magnetic resonance imaging
positron emission tomography
magnetic resonance
cystic fibrosis
pet ct