Trans-Ancestral Genetic Risk Factors for Treatment-Related Type 2 Diabetes Mellitus in Survivors of Childhood Cancer.

Cindy ImAchal NeupaneJessica L BaedkeBrian LennyAngela Delaney Stephanie B Dixon Eric J Chow Sogol Mostoufi-Moab Tianzhong Yang Melissa A Richard Maria Monica J Gramatges Philip J Lupo Noha Sharafeldin Smita BhatiaGregory T ArmstrongMelissa M Hudson Kristen K Ness Leslie L Robison Yutaka Yasui Carmen L Wilson Yadav Sapkota

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)

Our findings suggest therapy-related genetic risks contribute to the increased T2D burden among non-Hispanic Black childhood cancer survivors. Additional study of how therapy-related genetic susceptibility contributes to this disparity is needed.

Keyphrases

childhood cancer
young adults
genome wide
copy number
cardiovascular disease
gene expression
adipose tissue
type diabetes
dna methylation
metabolic syndrome
glycemic control
combination therapy
weight loss
chemotherapy induced