N -Feruloyl Serotonin Attenuates Neuronal Oxidative Stress and Apoptosis in Aβ 25-35 -Treated Human Neuroblastoma SH-SY5Y Cells.
Meitong HeChanhum ParkYusu ShinJi Hyun KimEun Ju ChoPublished in: Molecules (Basel, Switzerland) (2023)
Amyloid-beta (Aβ) aggregation and deposition have been identified as a critical feature in the pathology of Alzheimer's disease (AD), with a series of functional alterations including neuronal oxidative stress and apoptosis. N -feruloyl serotonin (FS) is a plant-derived component that exerts antioxidant activity. This study investigated the protective effects of FS on Aβ 25-35 -treated neuronal damage by regulation of oxidative stress and apoptosis in human neuroblastoma SH-SY5Y cells. The radical scavenging activities increased with the concentration of FS, exhibiting in vitro antioxidant activity. The Aβ 25-35 -treated SH-SY5Y cells exerted neuronal cell injury by decreased cell viability and elevated reactive oxygen species, but that was recovered by FS treatment. In addition, treatment of FS increased anti-apoptotic factor B-cell lymphoma protein 2 (Bcl-2) and decreased the pro-apoptotic factor Bcl-2-associated X protein. The FS attenuated Aβ-stimulated neuronal apoptosis by regulations of mitogen-activated protein kinase signaling pathways. Moreover, activated CREB-BDNF signaling was observed by the treatment of FS in Aβ 25-35 -induced SH-SY5Y cells. These results demonstrate that FS shows potential neuroprotective effects on Aβ 25-35 -induced neuronal damage by attenuation of oxidative stress and apoptosis, and suggest that FS may be considered a promising candidate for the treatment of AD.
Keyphrases
- oxidative stress
- induced apoptosis
- cell cycle arrest
- cell death
- endoplasmic reticulum stress
- diabetic rats
- pi k akt
- ischemia reperfusion injury
- dna damage
- signaling pathway
- cerebral ischemia
- reactive oxygen species
- cell proliferation
- anti inflammatory
- stem cells
- epithelial mesenchymal transition
- newly diagnosed
- mesenchymal stem cells
- cognitive decline
- high glucose
- combination therapy
- heat shock
- bone marrow
- deep learning
- amino acid
- mass spectrometry
- single molecule
- human health
- tyrosine kinase