Dysregulation and epigenetic reprogramming of NRF2 signaling axis promote acquisition of cisplatin resistance and metastasis in Head and Neck Squamous Cell Carcinoma.

Abdullah A Osman Emre Arslan Mason Bartels Chieko Michikawa Antje Lindemann Katarzyna Tomczak Wangjie Yu Vlad C Sandulache Wencai Ma Li Shen Jing Wang Anand Kamal Singh Mitchell J Frederick Nakia D Spencer Jeffrey J Kovacs Timothy P Heffernan William Fraser Symmans Kunal Rai Jeffrey N Myers

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

CDDP resistance and development of distant metastasis are associated with dysregulated and epigenetically reprogrammed KEAP1-NRF2 signaling pathway. A strategy targeting KEAP1/NRF2 pathway or glutamine metabolism deserves further clinical investigation in patients with CDDP resistant head and neck tumors.

Keyphrases

oxidative stress
signaling pathway
gene expression
dna methylation
lymph node
epithelial mesenchymal transition
cancer therapy
induced apoptosis
long noncoding rna
small molecule
endoplasmic reticulum stress