Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer's disease.

Suhyun KimHeejung ChunYunha KimYeyun KimUiyeol ParkJiyeon ChuMridula BhallaSeung-Hye ChoiAli Yousefian-JaziSojung KimSeung Jae HyeonSeungchan KimYeonseo KimYeon Ha JuSeung Eun LeeHyunbeom LeeKyungeun LeeSoo-Jin OhEun Mi HwangJunghee LeeC Justin LeeHoon Ryu

Published in: Molecular neurodegeneration (2024)

Taken together, our data indicates that Aβ-induced astrocytic autophagic plasticity is an important cellular event to modulate Aβ clearance and maintain cognitive function in AD mice.

Keyphrases

cell death
high glucose
diabetic rats
oxidative stress
electronic health record
endoplasmic reticulum stress
high fat diet induced
cognitive decline
big data
drug induced
endothelial cells
machine learning
skeletal muscle
data analysis