Circulating miR-26b-5p and miR-451a as diagnostic biomarkers in medullary thyroid carcinoma patients.

Z M BesharatS TrocchianesiA VerrientiR CiampiS CantaraC RomeiC SabatoT M R NovielloA PoA CitarellaF P CarusoI PanarielloF GiannoG CarpinoE GaudioM ChiacchiariniL MasuelliM SponzielloV PecceT RamoneF MainoF DottaM CeccarelliL PezzulloCosimo DuranteM G CastagnaR EliseiElisabetta Ferretti

Published in: Journal of endocrinological investigation (2023)

This study allowed the identification and validation of a signature of two circulating miRNAs, miR-26b-5p and miR-451a, in two independent cohorts reporting a significant diagnostic performance for MTC. The results of this study offer advancements in molecular diagnosis of MTC proposing a novel non-invasive tool to use in precision medicine.

Keyphrases

cell proliferation
long non coding rna
ejection fraction
long noncoding rna
end stage renal disease
newly diagnosed
peritoneal dialysis