Targeting microbiota-immune-synaptic plasticity to explore the effect of tea polyphenols on improving memory in the aged type 2 diabetic rat model.
Chenhui LvLe ChengWenjuan FengHaoran XieJie KouLili WangMengqian ShiXin SongXi WangShuangzhi ChenLushan XueCheng ZhangXuemin LiHaifeng ZhaoPublished in: Nutritional neuroscience (2024)
TP improves the memory in aged T2DM rat model. The mechanism may be related to the alteration of gut flora, which can inhibit hippocampal TLR4/NF-κB signaling to attenuate neuroinflammation, then improve synaptic plasticity. The study proposes that TP interventions aimed at manipulating the gut microbiota may hold great potential as an effective approach for preventing and treating this disease.
Keyphrases
- lps induced
- working memory
- inflammatory response
- signaling pathway
- toll like receptor
- nuclear factor
- cerebral ischemia
- immune response
- physical activity
- lipopolysaccharide induced
- oxidative stress
- pi k akt
- cognitive impairment
- blood brain barrier
- skeletal muscle
- human health
- adipose tissue
- risk assessment
- subarachnoid hemorrhage
- brain injury