NIR-Triggered Chemo-Photothermal Therapy by Thermosensitive Gold Nanostar@Mesoporous Silica@Liposome-Composited Drug Delivery Systems.
Zheng CaiYingwen ZhangZhimei HeLi-Ping JiangJun-Jie ZhuPublished in: ACS applied bio materials (2020)
Multimodal therapeutic strategy that combines drug delivery with other treatments (e.g., photodynamic therapy) is highly desired for biomedical applications. Here, we engineer a promising versatile platform based on gold nanostar liposome-entrapped mesoporous silica core-shell nanostructure (GSMS@lip). This system not only served as a container for therapeutic drugs (hydrophilic doxorubicin and hydrophobic docetaxel), but also had high photothermal conversion efficiency. Specifically, the thermosensitive liposome wrapping around mesoporous silica acted as a gatekeeper to encapsulate the drug molecules within the GSMS/Dox/Doc@lip drug delivery system. After exposure to near-infrared (NIR) laser, gold nanostar significantly raised the ambient temperature via photothermal conversion, thereby rupturing the thermosensitive liposomes and subsequently triggering the drug release. Benefiting from the combined chemo-photothermal therapy, this composite system showed enhanced cytotoxicity to MDA-MB-231 and MCF-7 cells. Furthermore, effective drug release and synergistic inhibition of tumor growth were achieved after intratumoral injection of GSMS/Dox/Doc@lip followed by NIR laser irradiation. The proposed multifunctional drug delivery system is capable of codelivering hydrophilic-hydrophobic drugs, providing a potential strategy for multimodal tumor therapies.
Keyphrases
- drug release
- drug delivery
- cancer therapy
- photodynamic therapy
- cell cycle arrest
- breast cancer cells
- induced apoptosis
- liquid chromatography
- fluorescence imaging
- pain management
- air pollution
- silver nanoparticles
- locally advanced
- ionic liquid
- particulate matter
- solid phase extraction
- high speed
- cell death
- high throughput
- mass spectrometry
- oxidative stress
- emergency department
- combination therapy
- radiation induced
- high resolution
- radiation therapy
- signaling pathway
- endoplasmic reticulum stress
- simultaneous determination
- electronic health record
- tandem mass spectrometry