An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons.
Scott G CanfieldMatthew J StebbinsMadeline G FaubionBenjamin D GastfriendSean P PalecekEric V ShustaPublished in: Fluids and barriers of the CNS (2019)
Importantly, each cell type in the NVU model was differentiated from the same donor iPSC source, yielding an isogenic model that could prove enabling for enhanced personalized modeling of the NVU in human health and disease.