TSG-6 Is Weakly Chondroprotective in Murine OA but Does not Account for FGF2-Mediated Joint Protection.

Linyi ZhuShannah DonhouAnnika BurleighJadwiga Miotla ZarebskaMarcia CurtinhaIda ParisiSumayya Nafisa KhanFrancesco Dell'AccioAnastasios ChanalarisTonia L Vincent

Published in: ACR open rheumatology (2020)

TSG-6 influences early gene regulation in the destabilized joint and exerts a modest late chondroprotective effect. Although strongly FGF2 dependent, TSG-6 does not explain the strong chondroprotective effect of FGF2.

Keyphrases

knee osteoarthritis