Icaritin sensitizes thrombin- and TxA2-induced platelet activation and promotes hemostasis via enhancing PLCγ2-PKC signaling pathways.

Zhixiang ZhuYanggan LuoHanjing LiaoRan GuoDoudou HaoZihan LuManjing HuangChenghong SunJingchun YaoNing WeiKewu ZengPengfei TuGuiming Zhang

Published in: Thrombosis and haemostasis (2024)

Icaritin can sensitize platelet activation induced by thrombin and TxA2 through enhancing the activation of PLCγ2-PKC signaling pathways and promote hemostasis, and has potential to be developed into a novel orally deliverable therapeutic agent for hemorrhages.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
high glucose
diabetic rats
risk assessment
human health