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Supplementation with Branched-Chain Amino Acids Induces Unexpected Deleterious Effects on Astrocyte Survival and Intracellular Metabolism with or without Hyperammonemia: A Preliminary In Vitro Study.

Ting WangKazuyuki SuzukiToshimi ChibaKeisuke KakisakaYasuhiro Takikawa
Published in: International journal of hepatology (2021)
Although further investigations of the effect of BCAA on human astrocytes with hyperammonemia are needed, our work demonstrates that BCAA supplementation has direct negative effects on astrocyte survival and intracellular metabolism.
Keyphrases
  • endothelial cells
  • amino acid
  • reactive oxygen species
  • free survival