Influence of the mesenchymal stromal cell source on the hematopoietic supportive capacity of umbilical cord blood-derived CD34+-enriched cells.
Sara BucarAndré Dargen de Matos BrancoMárcia F MataJoão Coutinho MilhanoÍris CaramalhoJoaquim M S CabralAna Fernandes-PlatzgummerCláudia Lobato da SilvaPublished in: Stem cell research & therapy (2021)
AT represents a promising alternative to BM as a source of MSC for co-culture protocols to expand/maintain HSPC ex vivo. On the other hand, UCM-derived MSC demonstrated inferior hematopoietic supportive capacity compared to MSC from adult tissues. Despite HPL being considered an alternative to FBS for clinical-scale manufacturing of MSC, further studies are needed to determine its impact on the hematopoietic supportive capacity of these cells.