Subconjunctival Sirolimus-Loaded Liposomes for the Treatment of Moderate-to-Severe Dry Eye Disease.
Alfredo Salcedo-LedesmaAndrea CórdobaNaomi C Zatarain-BarrónEnrique O Graue-HernándezYonathan GarfiasNorma Morales FloresGustavo A García-SánchezDiego García-SantistebanMónica A Linares-AlbaRodrigo García-SantistebanAlejandro NavasPublished in: Clinical ophthalmology (Auckland, N.Z.) (2023)
Our findings suggest that sub-conjunctival sirolimus-loaded liposomes are effective in reducing both signs and symptoms of dry eye in patients with poorly controlled moderate-to-severe DED, while avoiding other topical administration adverse effects. Further investigation with a larger sample size is required to determine long-term effects.