Effects of obesity, and of weight loss following bariatric surgery, on methylation of DNA from the rectal mucosa and in cell-free DNA from blood.
Khalil ElGendyFiona C MalcomsonSorena AfsharMichael D BradburnJohn Cummings MathersPublished in: International journal of obesity (2005) (2023)
BS reversed LINE1, POMC and LEP methylation in the rectal mucosa of patients with obesity to levels similar to those in individuals without obesity. These findings support current evidence of effects of BS-induced weight loss on reversibility of DNA methylation in other tissues. The DNA methylation changes in the rectal mucosa shows promise as a biomarker for objective assessment of effects of weight loss interventions on risk of cancer and other diseases.
Keyphrases
- weight loss
- bariatric surgery
- dna methylation
- roux en y gastric bypass
- genome wide
- gastric bypass
- obese patients
- gene expression
- rectal cancer
- weight gain
- glycemic control
- metabolic syndrome
- insulin resistance
- physical activity
- type diabetes
- adipose tissue
- squamous cell
- young adults
- high fat diet induced
- skeletal muscle
- stress induced
- lymph node metastasis
- nucleic acid
- endothelial cells