Presence of Potential G-Quadruplex RNA-Forming Motifs at the 5'-UTR of PP2Acα mRNA Repress Translation.
Sushree Prangya P PanyMahak SapraJitendar SharmaV DhamodharanSwati PatankarPushpangadan I PradeepkumarPublished in: Chembiochem : a European journal of chemical biology (2019)
RNA G-quadruplex (G4)-forming motifs present at the 5'-UTR of the protein phosphatase (PP2Ac) gene are the regulatory targets of the fragile X mental retardation protein (FMRP), which is weakly expressed in Fragile X patients. Herein, we report that the existence of such G4-forming sequence represses the translation of the PP2Acα gene. This study opens therapeutic avenues to design small molecule ligands that mimic the function of the FMRP.