Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population.
Sana AshiqMuhammad Farooq SabarPublished in: Molecular biology reports (2023)
In conclusion, variants in transcriptional and signaling genes were associated with Pakistani pediatric CHD patients that showed varied susceptibility between different clinical phenotypes of CHD. In addition, this study was the first report regarding the significant association between maternal hypertension and the LEFTY2 gene variant.
Keyphrases
- copy number
- blood pressure
- genome wide
- genome wide identification
- end stage renal disease
- newly diagnosed
- type diabetes
- chronic kidney disease
- ejection fraction
- transcription factor
- gene expression
- birth weight
- cardiovascular disease
- young adults
- pregnancy outcomes
- prognostic factors
- bioinformatics analysis
- body mass index
- oxidative stress
- insulin resistance
- metabolic syndrome
- patient reported outcomes
- glycemic control
- heat shock
- weight loss
- heat shock protein
- arterial hypertension