Clonal Hematopoiesis: A New Layer in the Liquid Biopsy Story in Lung Cancer.
Joshua M BaumlBenjamin LevyPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Cell-free DNA (cfDNA) is a unique biospecimen that contains multiple sources of DNA, including tumor, germline, fetal, and others. Clonal hematopoiesis, a process that leads to expansion of mutations in peripheral blood cells, is an additional source of DNA that adds a layer of complexity when interpreting results. Clin Cancer Res; 24(18); 4352-4. ©2018 AACRSee related article by Hu et al., p. 4437.
Keyphrases
- peripheral blood
- circulating tumor
- cell free
- induced apoptosis
- single molecule
- papillary thyroid
- cell cycle arrest
- squamous cell
- drinking water
- ultrasound guided
- circulating tumor cells
- dna repair
- endoplasmic reticulum stress
- ionic liquid
- cell death
- fine needle aspiration
- squamous cell carcinoma
- lymph node metastasis
- childhood cancer
- drug induced