Mapping and analysis of protein and gene profiles identify the important role of TGF-β in synovial invasion in pigmented villonodular synovitis.

Tao LiYan XiongJian LiXin TangYutong ZhongZhigang TangQiuping ZhangYubin Luo

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

This study provides overall protein and gene profiles of PVNS and identifies the crucial role of TGF-β in synovial invasion pathology. Exploring the related molecular mechanism may also reveal a new strategy or target for PVNS therapy.

Keyphrases

genome wide
transforming growth factor
cell migration
copy number
dna methylation
protein protein
amino acid
high resolution
binding protein
stem cells
epithelial mesenchymal transition
signaling pathway
cell therapy
bone marrow