Luteolin loaded on zinc oxide nanoparticles ameliorates non-alcoholic fatty liver disease associated with insulin resistance in diabetic rats via regulation of PI3K/AKT/FoxO1 pathway.

Esraa S A AhmedHebatallah E MohamedMostafa A Farrag

Published in: International journal of immunopathology and pharmacology (2022)

Lut/ZnO NPs have a hepatoprotective effect and may relieve the progression of NAFLD by alleviating insulin resistance, ameliorating the antioxidant status, and regulating the insulin signal pathway.

Keyphrases

oxide nanoparticles
pi k akt
diabetic rats
signaling pathway
oxidative stress
insulin resistance
type diabetes
cell proliferation
cell cycle arrest
drug delivery
adipose tissue
glycemic control
transcription factor
mouse model
skeletal muscle
polycystic ovary syndrome
room temperature
weight loss