The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling.

G CatanzaroZ M BesharatE MieleM ChiacchiariniA PoA CaraiC E MarrasM AntonelliM BadialiA RasoS MascelliD SchrimpfD StichelM TartagliaD CapperA von DeimlingF GiangasperoA MastronuzziF LocatelliElisabetta Ferretti

Published in: Neuropathology and applied neurobiology (2018)

These findings provide the first evidence that down-regulation of miR-139-5p in supratentorial pLGG drives cell proliferation by derepressing PI3K/AKT signalling.

Keyphrases

pi k akt
low grade
high grade
signaling pathway
cell proliferation
cell cycle arrest
intensive care unit
emergency department
cell cycle