Serum biomarkers for Modic changes in patients with chronic low back pain.

Jaro KarppinenKatri KoivistoJukka KetolaMarianne HaapeaMarkus PaananenKarl-Heinz HerzigMauro AliniJeffrey LotzStefan DudliDino SamartzisJuha RisteliMarja-Leena MajuriHarri AleniusEero KyllönenJyri JärvinenJaakko NiinimäkiSibylle Grad

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2021)

This is the first study to assess the blood serum biomarker profile in individuals with CLBP with MC. Several biomarkers were suppressed, while two markers (IL-1sRII and HGF) were elevated among MC patients, irrespective of MC type or size, with CLBP compared with asymptomatic controls.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors