Batch correction of single-cell sequencing data via an autoencoder architecture.

cell sequencing datasets and multiple measures for batch effect removal and biological variation conservation. ABC outperforms 10 state-of-the-art methods for this task including Seurat, scGen, ComBat, scanorama, scVI, scANVI, AutoClass, Harmony, scDREAMER, and CLEAR, correcting various types of batch effects while preserving intricate biological variations.