Clinical features, prognostic factors, and antibody effects in anti-mGluR1 encephalitis.
Marianna SpatolaMar Petit PedrolEstibaliz MaudesMateus SimabukuroSergio Muñiz-CastrilloAnne-Laurie PintoKlaus-Peter WandingerJuliane SpieglerPeter SchrammLívia Almeida DutraRaffaele IorioCornelia KornblumChristian G BienRomana HöftbergerFrank LeypoldtMaarten J TitulaerPeter Sillevis SmittJérôme HonnoratMyrna R RosenfeldFrancesc GrausJosep O DalmauPublished in: Neurology (2020)
Anti-mGluR1 encephalitis manifests as a severe cerebellar syndrome, often resulting in long-term disability and cerebellar atrophy. The antibodies are pathogenic and cause significant decrease of mGluR1 clusters in cultured neurons.