Humanized Patient-derived Xenograft Models of Disseminated Ovarian Cancer Recapitulate Key Aspects of the Tumor Immune Environment within the Peritoneal Cavity.

Mara P Steinkamp Irina Lagutina Kathryn J Brayer Fred A Schultz Danielle Burke Vernon S Pankratz Sarah F Adams Laurie G Hudson Scott A Ness Angela Wandinger-Ness

Published in: Cancer research communications (2023)

huPDX models are ideal preclinical models for testing novel therapies. They reflect the genetic heterogeneity of the patient population, enhance human myeloid differentiation, and recruit immune cells to the tumor microenvironment.

Keyphrases

endothelial cells
bone marrow
single cell
stem cells
gene expression
cell therapy
immune response
induced pluripotent stem cells
copy number
mesenchymal stem cells