Longitudinal tau accumulation and atrophy in aging and alzheimer disease.
Theresa M HarrisonRenaud La JoieAnne MaassSuzanne L BakerKaitlin SwinnertonLaura FentonTaylor J MellingerLauren EdwardsJulie PhamBruce L MillerGil D RabinoviciWilliam J JagustPublished in: Annals of neurology (2019)
Our findings indicate that tau accumulates even in amyloid-negative healthy OA and this process can be measured with in vivo tau-PET. In OA, tau accumulation and atrophy share a similar topography. In AD, tau increases more rapidly and accumulation occurs in frontal regions that are not yet undergoing significant atrophy. Ann Neurol 2019; 1-12 ANN NEUROL 2019;85:229-240.