Leaky gut and inflammatory biomarkers in a medication overuse headache model in male rats.

Doğa Vuralli Hale Gök Dağidir Elif Abbasoğlu Topa Hayrunnisa Bolay Belen

Published in: Turkish journal of medical sciences (2023)

Elevated serum occludin and LBP levels and brain IL-17 and HMGB1 levels indicate a possible role of leaky gut and inflammation in an MOH model in male rats. Additionally, a significant correlation between pain behavior and markers of inflammation and intestinal hyperpermeability, supports the role of inflammation and leaky gut in MOH pathophysiology.

Keyphrases

oxidative stress
chronic pain
healthcare
pain management
emergency department
white matter
neuropathic pain
multiple sclerosis
spinal cord
blood brain barrier
adverse drug
functional connectivity
cerebral ischemia