Chronic Diclofenac Exposure Increases Mitochondrial Oxidative Stress, Inflammatory Mediators, and Cardiac Dysfunction.
Phung N ThaiLu RenWilson XuJames OvertonValeriy TimofeyevCarol E NaderMichael HaddadJun YangAldrin V GomesBruce D HammockNipavan ChiamvimonvatPadmini SirishPublished in: Cardiovascular drugs and therapy (2021)
Together, chronic treatment with DIC resulted in severe cardiotoxicity, which was mediated, in part, by an increase in mitochondrial oxidative stress.