Administration and effects of beta blockers and oxandrolone in severely burned adults: a post hoc analysis of the RE-ENERGIZE trial.
Gabriel HundeshagenElisabeth BlearsViktoria MertinAndrew G DayAlen PalackicChristian TapkingValentin HaugUlrich KneserBjörn BliesenerAdriana C PanayiAriel AballayFrancois DepretChristian StoppeDaren K HeylandPublished in: Burns & trauma (2024)
The use of OX, BB and BBOX is common within the adult burn patient population, with its use varying considerably across sites worldwide. Our findings found mixed associations between outcomes and the use of BB and OX in adult burn patients, with lower acute and 6-month-mortality with BB and longer times to discharge with OX. Further research into these pharmacological modulators of the pathophysiological response to severe burn injury is indicated.
Keyphrases
- growth factor
- wound healing
- recombinant human
- liver failure
- low density lipoprotein
- drug induced
- small molecule
- clinical trial
- study protocol
- cardiovascular events
- case report
- early onset
- phase ii
- phase iii
- childhood cancer
- coronary artery disease
- metabolic syndrome
- angiotensin converting enzyme
- adipose tissue
- hepatitis b virus
- extracorporeal membrane oxygenation
- angiotensin ii