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Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation.

Manikanda Raja Keerthi RajaGourab GuptaGrace AtkinsonKatie KathreinAlissa ArmstrongMichael GowerIgor RoninsonEugenia BroudeMenqiang ChenHao JiChang-Uk LimHongjun WangDaping FanPeisheng XuJie LiGang ZhouHexin Chen
Published in: bioRxiv : the preprint server for biology (2024)
Interleukin 1α dictates macrophage behavior, influencing an immunosuppressive microenvironment in breast cancer, suggesting it as a treatment target.
Keyphrases
  • adipose tissue
  • stem cells
  • dendritic cells
  • endothelial cells
  • immune response