Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation.

Manikanda Raja Keerthi RajaGourab GuptaGrace AtkinsonKatie KathreinAlissa ArmstrongMichael GowerIgor RoninsonEugenia BroudeMenqiang ChenHao JiChang-Uk LimHongjun WangDaping FanPeisheng XuJie LiGang ZhouHexin Chen

Published in: bioRxiv : the preprint server for biology (2024)

Interleukin 1α dictates macrophage behavior, influencing an immunosuppressive microenvironment in breast cancer, suggesting it as a treatment target.

Keyphrases

adipose tissue
stem cells
dendritic cells
endothelial cells
immune response