Phase I/Ib Study of the Efficacy and Safety of Buparlisib and Ibrutinib Therapy in MCL, FL, and DLBCL with Serial Cell-Free DNA Monitoring.
Caitlin M StewartLaure MichaudKarissa A WhitingReiko NakajimaChelsea NicholsStephanie De FrankPaul A HamlinMatthew J MatasarJohn F GerecitanoPamela DrullinskyAudrey HamiltonDavid StrausSteven M HorwitzAnita KumarCraig H MoskowitzAlison MoskowitzAndrew D ZelenetzJurgen RademakerGilles Andre SallesVenkatraman SeshanHeiko SchöderAnas YounesDana W Y TsuiConnie Lee BatleviPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
BTK and pan-PI3K inhibition in mantle cell lymphoma demonstrates a promising efficacy signal. Addition of BCL2 inhibitors to a BTK and pan-PI3K combination remain suitable for further development in mantle cell lymphoma.