High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections.
Else Quist-PaulsenPål AukrustAnne-Marte Bakken KranOona DunlopVidar OrmaasenBirgitte StiksrudØivind MidttunThor UelandPer Magne UelandTom Eirik MollnesAnne Ma Dyrhol-RiisePublished in: Journal of neuroinflammation (2018)
We show that parenchymal and meningeal inflammations in CNS share a characteristic cytokine profile with a general immune response in the CSF with limited influence from the systemic circulation. IFN-γ activity, assessed by neopterin and IP-10 levels, may play a role in the activation of the KP pathway in these patients, potentially mediating neurotoxic effects.
Keyphrases
- cerebrospinal fluid
- immune response
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- dendritic cells
- liver failure
- prognostic factors
- peritoneal dialysis
- ms ms
- respiratory failure
- drug induced
- blood brain barrier
- intensive care unit
- inflammatory response
- hepatitis b virus
- acute respiratory distress syndrome