Synthesis, Cytotoxic Analysis, and Molecular Docking Studies of Tetrazole Derivatives via N-Mannich Base Condensation as Potential Antimicrobials.
Ashraf Atef HatamlehDunia Al FarrajSarah Salah Al-SaifSathishKumar ChidambaramSurendrakumar RadhakrishnanIdhayadhulla AkbarPublished in: Drug design, development and therapy (2020)
Generally, 1b, 2a, and 2b exhibited impressive inhibitory capabilities in antibacterial, antifungal, and cytotoxic screenings relative to the reference compounds. The results of the molecular docking studies and both the microbial and anticancer screenings indicate that these novel derivatives could be developed into potential therapeutic agents for medical applications.