Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein-Ru(carbene) adduct.
Matthew P SullivanMichél K NieuwoudtGraham A BowmakerNelson Y S LamDianna TruongDavid C GoldstoneChristian G HartingerPublished in: Chemical communications (Cambridge, England) (2018)
The first X-ray structures of adducts formed between a RuII(N-heterocyclic carbene)(η6-p-cymene) compound and a protein are reported. Coordination to the protein induced the cleavage of the cymene ligand and EPR spectroscopy demonstrated the oxidation of the Ru centre.