Evaluating the Efficacy of L-N-acetylcysteine and Dexamethasone in Combination to Provide Otoprotection for Electrode Insertion Trauma.

Adrien A EshraghiDavid Shahal Camron M DaviesJeenu MittalViraj N Shah Erdogan BulutCarolyn GarnhamPriyanka SinhaDibyanshi MishraHannah MarwedeRahul Mittal

Published in: Journal of clinical medicine (2020)

A combination containing L-NAC and Dex is effective in protecting sensory cells at lower protective doses than each compound separately. These compounds can be combined allowing a decrease of potential side effects of each compound and providing significant otoprotection for EIT.

Keyphrases

induced apoptosis
cell cycle arrest
transcription factor
endoplasmic reticulum stress
signaling pathway
trauma patients