Adults with spinal muscular atrophy: a large-scale natural history study shows gender effect on disease.
Lorenzo MaggiLuca BelloSilvia BonannoAlessandra GovoniClaudia CaponnettoLuigia PassamanoMarina GrandisFrancesca TrojsiFederica CerriAlice GardaniManfredi FerraroGiulio GadaletaVittoria ZangaroLuca CaumoMariantonietta MaioliRaffaella TanelElena SaccaniMegi MeneriVeria VacchianoGiulia RicciGianni SorarùEustachio D'ErricoSara BortolaniGiovanni PavesiCinzia GelleraRiccardo ZaninStefania P CortiMauro SilvestriniLuisa PolitanoAngelo SchenoneStefano Carlo PrevitaliAngela BerardinelliMara TurriLorenzo VerrielloMichela CocciaRenato MantegazzaRocco LiguoriMassimiliano MirabellaGianni MarrosuFrancesco Danilo TizianoGabriele SicilianoIsabella Laura SimoneTiziana MonginiGiacomo ComiElena PegoraroPublished in: Journal of neurology, neurosurgery, and psychiatry (2022)
Our data showed a relevant gender effect on SMA motor function with higher disease severity in males especially in the young adult age and in SMA3 patients.