Anastomotic leak in colorectal cancer surgery: Contribution of gut microbiota and prediction approaches.
Patricia I Hernández-GonzálezJosé BarquínAna Ortega-FerreteVíctor PatónManuel Ponce-AlonsoBeatriz Romero-HernándezJuan OcañaAlejandra CaminoaElisa CondeJavier GaleanoRosa Del CampoJuan Carlos García-PérezPublished in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2023)
Biopsy samples from surgical margins, rather than faecal samples, are the most appropriate samples for exploring the contribution of the intestinal microbiota to CAL. Enterococci are only enriched in the anastomosis after surgery, and their collagenases and proteases are involved in the degradation of the anastomotic scar.