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Ascending single dose pharmacokinetics of cytisine in healthy adult smokers.

Soo Hee JeongJanie SheridanChristopher R BullenDavid A L NewcombeNatalie WalkerMalcolm Drummond Tingle
Published in: Xenobiotica; the fate of foreign compounds in biological systems (2019)
1. Cytisine, a partial agonist for the α4β2-nAChR, is used as a smoking cessation medication. Cytisine's current dosing is complex and involves taking 1.5 mg several times a day. The aim of this study was to explore the effect of dose on the pharmacokinetics and safety of cytisine after a single dose in healthy adult smokers. 2. Participants were assigned to one of three groups (n = 6 in each group) to receive a single oral dose of 1.5, 3 or 4.5 mg of cytisine. Blood samples were collected up to 24 h post dose. Pulse, blood pressure and respiratory rate were measured. Adverse effects were recorded. 3. Cytisine reached peak plasma concentration 1-2 h post dose in all participants irrespective of dose, with no dose-dependent changes in the elimination phase. Mean (SD) cytisine exposure (AUC0-24h) were 81.9 (15.8), 181.9 (40.8) and 254.5 (48.1) ng.h/mL following 1.5, 3 and 4.5 mg, respectively. 4. Cytisine appears to have predictable pharmacokinetics following a single dose of up to 4.5 mg and may be safe given as a single 4.5 mg dose, which is threefold greater than the recommended dose taken at one time. This study is registered in ClinicalTrials.gov (ID:NCT02585024).
Keyphrases
  • smoking cessation
  • blood pressure
  • type diabetes
  • healthcare
  • adipose tissue
  • coronary artery
  • hypertensive patients
  • skeletal muscle
  • respiratory tract
  • pulmonary arterial hypertension
  • electronic health record