Humanized Patient-derived Xenograft Models of Disseminated Ovarian Cancer Recapitulate Key Aspects of the Tumor Immune Environment within the Peritoneal Cavity.

Mara P Steinkamp Irina Lagutina Kathryn J Brayer Fred A Schultz Danielle Burke Vernon S Pankratz Sarah F Adams Laurie G Hudson Scott A Ness Angela Wandinger-Ness

Published in: Cancer research communications (2023)

huPDX models are ideal preclinical models for testing novel therapies. They reflect the genetic heterogeneity of the patient population, enhance human myeloid differentiation, and recruit immune cells to the tumor microenvironment.

Keyphrases

endothelial cells
dendritic cells
bone marrow
acute myeloid leukemia
case report
stem cells
single cell
genome wide
cell therapy
induced pluripotent stem cells
dna methylation
copy number