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Association between serum neuron-specific enolase, age, overweight, and structural MRI patterns in 901 subjects.

Johanna HoffmannDeborah JanowitzSandra Van der AuweraKatharina WittfeldMatthias NauckNele FriedrichMohamad HabesChristos DavatzikosJan TerockMartin BahlsAnnemarie GoltzAngela KuhlaHenry VölzkeHans Jörgen Grabe
Published in: Translational psychiatry (2017)
sNSE was determined in 901 subjects (499 women, 22-81 years, BMI 18-48 kg/m2), participating in a population-based study (SHIP-TREND). We report age-specific patterns of sNSE levels between males and females. Females showed augmenting, males decreasing sNSE levels associated with age (males: p = 0.1052, females: p = 0.0363). sNSE levels and BMI were non-linearly associated, showing a parabolic association and decreasing sNSE levels at BMI values >25 (p = 0.0056). In contrast to our hypotheses, sNSE levels were not associated with total GMV, aging, or AD-like patterns. Pathomechanisms discussed are: sex-specific hormonal differences, neuronal damage/differentiation, or impaired cerebral glucose metabolism. We assume a sex-dependence of age-related effects to the brain. Further, we propose in accordance to previous studies an actual neuronal damage in the early stages of obesity. However, with progression of overweight, we assume more profound effects of excess body fat to the brain.
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