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Mitotic exit: Determining the PP2A dephosphorylation program.

Gislene PereiraElmar Schiebel
Published in: The Journal of cell biology (2016)
In mitotic exit, proteins that were highly phosphorylated are sequentially targeted by the phosphatase PP2A-B55, but what underlies substrate selection is unclear. In this issue, Cundell et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201606033) identify the determinants of PP2A-B55's dephosphorylation program, thereby influencing spindle disassembly, nuclear envelope reformation, and cytokinesis.
Keyphrases
  • quality improvement
  • cell cycle
  • single cell
  • cell therapy
  • stem cells
  • cell proliferation
  • protein kinase