Restoration of HDAC2 and Nrf2 by andrographolide overcomes corticosteroid resistance in chronic obstructive pulmonary disease.

Wupeng LiaoAlbert Y H LimW S Daniel TanJohn AbisheganadenWai Shiu Fred Wong

Published in: British journal of pharmacology (2020)

We report here for the first time a novel corticosteroid re-sensitization property of andrographolide in human PBMCs and provide mechanistic evidence to support clinical evaluation of andrographolide in reversing steroid resistance in COPD.

Keyphrases

endothelial cells
chronic obstructive pulmonary disease
oxidative stress
lung function
induced pluripotent stem cells