VCP increases or decreases tau seeding using specific cofactors.
Sushobhna BatraJaime Vaquer-AliceaVictor A ManonOmar M KashmerAndrew LemoffNigel J CairnsCharles L WhiteMarc I DiamondPublished in: bioRxiv : the preprint server for biology (2023)
VCP uses distinct cofactors to determine seed replication efficiency, consistent with a dedicated cytoplasmic processing complex that directs seeds towards dissolution vs. amplification.
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