In silico Analysis of Publicly Available Transcriptomics Data Identifies Putative Prognostic and Therapeutic Molecular Targets for Papillary Thyroid Carcinoma.

Asma AlmansooriPoorna Manasa BhamidimarriRiyad Bendardaf Rifat Akram Hamoudi

Published in: International journal of general medicine (2022)

Transcriptomics analysis identified putative prognostic targets including EGFR, PTK2B, BCL2, KCNQ1, KCNN4 and CACNA1D. EGFR, PTK2B and KCN44 were validated using thyroid cancer clinical biopsies. The drug search identified FDA approved drugs including Vandetanib in addition to others that may prove useful in treating the disease.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
single cell
tyrosine kinase
lymph node
lymph node metastasis
electronic health record
genome wide
molecular docking
big data
drug induced
gene expression
deep learning